In this section, you will find the latest news, biotech resources and developments related to TECNIC. We are dedicated to reporting on our technological advances, strategic collaborations, relevant events and other significant aspects of our work in the biotechnology sector. Keep up to date with our initiatives and how we contribute to progress in bioprocess research and development.
Cassette
We understand the importance of flexibility and efficiency in laboratory processes. That's why our equipment is designed to be compatible with Cassette filters, an advanced solution for a variety of filtration applications. Although we do not manufacture the filters directly, our systems are optimized to take full advantage of the benefits that Cassette filters offer.
Cassette filters are known for their high filtration capacity and efficiency in separation, making them ideal for ultrafiltration, microfiltration, and nanofiltration applications. By integrating these filters into our equipment, we facilitate faster and more effective processes, ensuring high-quality results.
Our equipment, being compatible with Cassette filters, offers greater versatility and adaptability. This means you can choose the filter that best suits your specific needs, ensuring that each experiment or production process is carried out with maximum efficiency and precision.
Moreover, our equipment stands out for its 100% automation capabilities. Utilizing advanced proportional valves, we ensure precise control over differential pressure, transmembrane pressure, and flow rate. This automation not only enhances the efficiency and accuracy of the filtration process but also significantly reduces manual intervention, making our systems highly reliable and user-friendly.
Hollow Fiber
We recognize the crucial role of flexibility and efficiency in laboratory processes. That's why our equipment is meticulously designed to be compatible with Hollow Fiber filters, providing an advanced solution for a broad spectrum of filtration applications. While we don't directly manufacture these filters, our systems are finely tuned to harness the full potential of Hollow Fiber filters.
Hollow Fiber filters are renowned for their exceptional performance in terms of filtration efficiency and capacity. They are particularly effective for applications requiring gentle handling of samples, such as in cell culture and sensitive biomolecular processes. By integrating these filters with our equipment, we enable more efficient, faster, and higher-quality filtration processes.
What sets our equipment apart is its 100% automation capability. Through the use of sophisticated proportional valves, our systems achieve meticulous control over differential pressure, transmembrane pressure, and flow rate. This level of automation not only boosts the efficiency and precision of the filtration process but also significantly diminishes the need for manual oversight, rendering our systems exceptionally reliable and user-friendly.
The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.
Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture.
The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.
Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture.
The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.
Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture.
The microbial configuration of the eLab Advanced is equipped with a Rushton turbine specifically designed for high-oxygen-demand processes such as bacterial and yeast fermentations. The radial-flow impeller generates strong mixing and intense gas dispersion, promoting high oxygen transfer rates and fast homogenization of nutrients, antifoam and pH control agents throughout the vessel. This makes it particularly suitable for robust microbial strains operating at elevated agitation speeds and aeration rates.
Operators can adjust agitation and gas flow to reach the required kLa while maintaining consistent mixing times, even at high cell densities. This configuration is an excellent option for users who need a powerful, reliable platform to develop and optimize microbial processes before transferring them to pilot or production scales.
The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.
Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture.
Defined considering non-hazardous process fluids (PED group 2) and jacket steam/superheated water (PED group 5), depending on configuration and project scope.
| Mode | Element | Working pressure (bar[g]) | Working pressure (psi[g]) | T max (°C / °F) |
|---|---|---|---|---|
| Process | Vessel | 0 / +2.5 | 0 / +36.3 | +90 / 194 |
| Process | Jacket | 0 / +3.8 | 0 / +55.1 | +90 / 194 |
| Sterilisation | Vessel | 0 / +2.5 | 0 / +36.3 | +130 / 266 |
| Sterilisation | Jacket | 0 / +3.8 | 0 / +55.1 | +150 / 302 |
| Working volume | MU (Cell culture), reference | MB (Microbial), reference |
|---|---|---|
| 10 L | 0 to 300 rpm | 0 to 1000 rpm |
| 20 L | 0 to 250 rpm | 0 to 1000 rpm |
| 30 L | 0 to 200 rpm | 0 to 1000 rpm |
| 50 L | 0 to 180 rpm | 0 to 1000 rpm |
The equipment typically includes 4 integrated variable-speed peristaltic pumps for sterile additions (acid/base/antifoam/feeds). Actual flow depends on selected tubing and calibration.
| Parameter | Typical value | Notes |
|---|---|---|
| Quantity | 4 units (integrated) | In control tower; assignment defined by configuration |
| Speed | 0-300 rpm | Variable control from eSCADA |
| Minimum flow | 0-10 mL/min | Example with 0.8 mm ID tubing; depends on tubing and calibration |
| Maximum flow | Up to ~366 mL/min | Example with 4.8 mm ID tubing; actual flow depends on calibration |
| Operating modes | OFF / AUTO / MANUAL / PROFILE | AUTO typically associated to pH/DO/foam loops or recipe |
| Functions | PURGE, calibration, totaliser, PWM | PWM available for low flow setpoints below minimum operating level |
For microbial culture (MB), gas flow controllers (MFC) are typically sized based on VVM targets. Typical reference VVM range: 0.5-1.5 (to be confirmed by process).
| Working volume (L) | VVM min | VVM max | Air (L/min) | O2 (10%) (L/min) | CO2 (20%) (L/min) | N2 (10%) (L/min) |
|---|---|---|---|---|---|---|
| 10 | 0.5 | 1.5 | 5-15 | 0.5-1.5 | 1-3 | 0.5-1.5 |
| 20 | 0.5 | 1.5 | 10-30 | 1-3 | 2-6 | 1-3 |
| 30 | 0.5 | 1.5 | 15-45 | 1.5-4.5 | 3-9 | 1.5-4.5 |
| 50 | 0.5 | 1.5 | 25-75 | 2.5-7.5 | 5-15 | 2.5-7.5 |
Instrumentation is configurable. The following list describes typical sensors integrated in standard configurations, plus common optional PAT sensors.
| Variable / function | Typical technology / interface | Status (STD/OPT) |
|---|---|---|
| Temperature (process/jacket) | Pt100 class A RTD | STD |
| Pressure (vessel/lines) | Pressure transmitter (4-20 mA / digital) | STD |
| Level (working volume) | Adjustable probe | STD |
| pH | Digital pH sensor (ARC or equivalent) | STD |
| DO (pO2) | Digital optical DO sensor (ARC or equivalent) | STD |
| Foam | Conductive/capacitive foam sensor | STD |
| Weight / mass balance | Load cell (integrated in skid) | STD |
| pCO2 | Digital pCO2 sensor (ARC or equivalent) | OPT |
| Biomass (permittivity) | In-line or in-vessel sensor | OPT |
| VCD / TCD | In-situ cell density sensors | OPT (MU) |
| Off-gas (O2/CO2) | Gas analyser for OUR/CER | OPT |
| ORP / Redox | Digital ORP | OPT |
| Glucose / Lactate | PAT sensor | OPT |
The platform incorporates TECNIC eSCADA (typically eSCADA Advanced for ePILOT) to operate actuators and control loops, execute recipes and manage process data.
Support for 21 CFR Part 11 / EU GMP Annex 11 is configuration- and project-dependent and requires customer procedures and validation (CSV).
Utilities depend on final configuration (e.g., AutoSIP vs External SIP) and destination market (EU vs North America). The following values are typical reference points.
| Utility | Typical service / configuration | Pressure | Flow / power | Notes |
|---|---|---|---|---|
| Electrical | EU base: 400 VAC / 50 Hz (3~) | N/A | AutoSIP: 12 kW; External SIP: 5 kW | NA option: 480 VAC / 60 Hz; cabinet/wiring per NEC/NFPA 70; UL/CSA as required |
| Process gases | Air / O2 / CO2 / N2 | Up to 2.5 bar(g) (36.3 psi) | According to setpoint | Typical OD10 pneumatic connections; final list depends on package |
| Instrument air | Pneumatic valves | Up to 6 bar(g) (87.0 psi) | N/A | Dry/filtered air recommended |
| Cooling water | Jacket cooling water | 2 bar(g) (29.0 psi) | 25 L/min (6.6 gpm) | 6-10 °C (43-50 °F) typical |
| Cooling water | Condenser cooling water | 2 bar(g) (29.0 psi) | 1 L/min (0.26 gpm) | 6-10 °C (43-50 °F) typical |
| Steam (External SIP) | Industrial steam | 2-3 bar(g) (29.0-43.5 psi) | 30 kg/h (66 lb/h) | For SIP sequences |
| Steam (External SIP) | Clean steam | 1.5 bar(g) (21.8 psi) | 8 kg/h (18 lb/h) | Depending on plant strategy |
Depending on destination and project scope, the regulatory basis may include European Directives (CE) and/or North American codes. The exact list is confirmed per project and stated in the Declaration(s) of Conformity when applicable.
| Scope | EU (typical references) | North America (typical references) |
|---|---|---|
| Pressure equipment | PED 2014/68/EU | ASME BPVC Section VIII (where applicable) |
| Hygienic design | Hygienic design good practices | ASME BPE (reference for bioprocessing) |
| Machine safety | Machinery: 2006/42/EC (until 13/01/2027) / (EU) 2023/1230 | OSHA expectations; NFPA 79 (industrial machinery) - project dependent |
| Electrical / EMC | LVD 2014/35/EU; EMC 2014/30/EU | NEC/NFPA 70; UL/CSA components and marking as required |
| Materials contact | EC 1935/2004 + EC 2023/2006 (GMP for materials) where applicable | FDA 21 CFR (e.g., 177.2600 for elastomers) - materials compliance |
| Software / CSV | EU GMP Annex 11 (if applicable) | 21 CFR Part 11 (if applicable) |
ePILOT BR is configured per project. To define the right MU/MB package, volumes and options (utilities, sensors, software and compliance), please contact TECNIC with your URS or request the configuration questionnaire.
The information provided above is for general reference only and may be modified, updated or discontinued at any time without prior notice. Values and specifications are indicative and may vary depending on project scope, configuration and applicable requirements. This content does not constitute a binding offer, warranty, or contractual commitment. Any final specifications, deliverables and acceptance criteria will be confirmed in the corresponding quotation, technical documentation and/or contract documents.
The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.
Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture.
[contact-form-7 id="c5c798c" title="ePilot BR configuration questionnaire"]
The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.
Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture.
The ePlus Mixer platform combines an ePlus Mixer control tower with Tank frames and eBag 3D consumables. Tank can be supplied in square or cylindrical configurations (depending on project) to match the bag format.
| Tank model | Nominal volume | Minimum volume to start agitation* |
|---|---|---|
| Tank 50 L | 50 L | 15 L |
| Tank 100 L | 100 L | 20 L |
| Tank 200 L | 200 L | 30 L |
| Tank 500 L | 500 L | 55 L |
Reference limits are defined for the ePlus Mixer and the Tank. It is recommended to validate the specific limits of the selected eBag 3D and single-use sensors for the customer’s process.
| Element | Operating pressure | Maximum pressure (safety) | Maximum working temperature |
|---|---|---|---|
| ePlus Mixer (control tower) | ATM | 0.5 bar(g) | 90 °C |
| Tank | ATM | 0.5 bar(g) | 45 °C |
| Jacket (if applicable) | N/A | 1.5 bar | Depends on utilities / scope |
Non-invasive magnetic agitation, the impeller is integrated in the eBag 3D Mixer format, avoiding mechanical seals. Agitation speed is controlled from the HMI, with start interlocks linked to the tank model and minimum volume.
Weight and derived volume control are performed using 4 load cells integrated in the tank frame legs and a weight indicator. Tare functions are managed from the HMI to support preparation steps and additions by mass.
| Component | Reference model | Key parameters |
|---|---|---|
| Load cells (x4) | Mettler Toledo SWB505 (stainless steel) | 550 kg each, output 2 mV/V, IP66 |
| Weight indicator | Mettler Toledo IND360 DIN | Acquisition and HMI display, tare and “clear last tare” |
The platform includes integrated pumps for additions and circulation. Final tubing selection and calibration define the usable flow range.
| Parameter | Reference | Notes |
|---|---|---|
| Quantity | 3 units | Integrated in the control tower |
| Pump head | HYB101 (Hygiaflex) | Example tubing: ID 4.8 mm, wall 1.6 mm |
| Max speed | 300 rpm | Speed control reference: 0–5 V |
| Max flow (example) | 365.69 mL/min | Depends on tubing and calibration |
| Parameter | Reference |
|---|---|
| Model | EBARA MR S DN25 |
| Power | 0.75 kW |
| Flow | Up to 42 L/min |
| Pressure | Up to 1 bar |
Tank can be supplied with a jacket (single or double jacket options). The thermal circuit includes control elements and a heat exchanger, enabling temperature conditioning depending on utilities and project scope.
Single-use sensors can be integrated via dedicated modules. The following references describe typical sensors and interfaces listed in the datasheet.
| Variable | Reference model | Interface / protocol | Supply | Operating temperature | IP |
|---|---|---|---|---|---|
| pH | OneFerm Arc pH VP 70 NTC (SU) | Arc Module SU pH, Modbus RTU | 7–30 VDC | 5–50 °C | IP67 |
| Conductivity | Conducell-P SU (SU) | Arc Module Cond-P SU, Modbus RTU | 7–30 VDC | 0–60 °C | IP64 |
| Temperature | Pt100 ø4 × 52 mm, M8 (non-invasive) | Analog / acquisition module | Project dependent | Project dependent | Project dependent |
The ePlus SUM control tower integrates an industrial PLC and touch HMI. Standard operation supports Manual / Automatic / Profile modes, with optional recipe execution depending on selected software scope.
Installation requirements depend on jacket and temperature scope and the customer layout. The following values are typical references.
| Utility | Pressure | Flow | Connections | Notes |
|---|---|---|---|---|
| Electrical supply | N/A | Reference: 18 A | 380–400 VAC, 3~ + N, 50 Hz | Confirm per final configuration and destination market |
| Ethernet | N/A | N/A | RJ45 | OPC server, LAN integration |
| Tap water | 2.5 bar | N/A | 1/2" (hose connection) | Jacket fill and services, tank volume about 25 L |
| Cooling water | 2–4 bar | 10–20 L/min | 2 × 3/4" (hose connection) | Heat exchanger and jacket cooling |
| Process air | 2–4 bar | N/A | 1/2" quick coupling | Used for jacket emptying |
| Drain | N/A | N/A | 2 × 3/4" (hose connection) | For draining |
| Exhaust | N/A | N/A | N/A | Optional (depending on project) |
| Stack light (optional) | N/A | N/A | N/A | 3-colour indication, as per scope |
Deliverables depend on scope and project requirements. The following items are typical references included in the technical documentation package.
The ePlus Mixer scope is defined per project. To select the right tank size, bag format, sensors and optional jacket and software, please share your URS or request the configuration questionnaire.
The information provided above is for general reference only and may be modified, updated or discontinued at any time without prior notice. Values and specifications are indicative and may vary depending on project scope, configuration and applicable requirements. This content does not constitute a binding offer, warranty, or contractual commitment. Any final specifications, deliverables and acceptance criteria will be confirmed in the corresponding quotation, technical documentation and/or contract documents.
The cellular configuration of the eLab Advanced is equipped with a pitched-blade impeller designed to support efficient mixing for cell culture processes in both laboratory development and early scale-up. The blade geometry promotes mainly axial flow, helping to distribute gases, nutrients and pH control agents uniformly throughout the vessel while keeping shear stress at a moderate level. This makes it suitable for mammalian, insect and other shear-sensitive cell lines when operated with appropriate agitation and aeration settings. In combination with the vessel aspect ratio and baffle design, the pitched blade supports stable foaming behavior and reproducible oxygen transfer, which is essential when comparing batches or transferring processes between working volumes.
Operators can fine-tune agitation speed to balance oxygen demand and mixing time without excessively increasing mechanical stress on the culture.
Move from laboratory to pilot and production with a structured range: eLab (0.5–10 L), ePilot (30–50 L), eProd (100–2000 L). Scale with clearer continuity across platforms, supporting the same key control priorities and configuration paths for a smoother transition between volumes.
Laboratory equipment - up to 10L
Pilot equipment - up to 50L
Production equipment - up to 4000L
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